Of all the developments in longevity medicine in the past decade, few have generated as much scientific interest — or as compelling clinical results — as NAD+ IV therapy.

NAD+ (nicotinamide adenine dinucleotide) is not a new supplement or a wellness trend. It is one of the most fundamental molecules in human biology, present in every cell of the body and central to processes that determine how fast we age, how well our brains function, and how effectively our bodies repair themselves. And the evidence that restoring declining NAD+ levels can meaningfully reverse many of the hallmarks of aging is growing rapidly.

At Neo Clinics in Girona, we offer NAD+ IV therapy as part of our longevity and regenerative medicine programmes. This article explains the science, the benefits, and exactly what you can expect from treatment.

What Is NAD+?

NAD+ is a coenzyme found in every living cell. It plays a critical role in two of the most essential processes in human biology:

1. Cellular Energy Production

NAD+ is a key component of the mitochondrial energy cycle — the process by which your cells convert nutrients from food into ATP, the energy currency the body runs on. Without adequate NAD+, mitochondrial function declines, cellular energy production falls, and the result is the fatigue, cognitive decline, and physical deterioration associated with aging.

2. DNA Repair and Cellular Maintenance

NAD+ is required for the activity of a family of enzymes called sirtuins — often described as “longevity genes” — that regulate cellular repair, inflammation, and metabolic function. It is also required for PARP enzymes, which are critical to repairing DNA damage caused by oxidative stress and environmental toxins. Without sufficient NAD+, DNA damage accumulates and cellular aging accelerates.

Why Do NAD+ Levels Decline?

NAD+ levels decline progressively and significantly with age. Research has shown that by the time we reach 50, our NAD+ levels are typically only half of what they were in our twenties — and by 80, they may be as low as 1–10% of youthful levels.

This decline is driven by several factors including chronic inflammation, oxidative stress, alcohol consumption, poor sleep, sedentary lifestyle, and the simple passage of time. The consequences are now understood to be far-reaching: reduced cellular energy, impaired DNA repair, increased inflammation, cognitive decline, and reduced metabolic efficiency — in other words, the biology of aging itself.

Why IV Delivery Makes the Difference

NAD+ is available in oral supplement form, most commonly as NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside). These oral precursors are genuinely useful for maintenance and mild supplementation. However, they have significant limitations:

• Oral NAD+ precursors are metabolised by the gut and liver before reaching systemic circulation, meaning only a fraction reaches the cells that need it most
• The conversion of oral precursors to active NAD+ is an indirect, multi-step process that varies considerably between individuals
• The therapeutic concentrations required for meaningful clinical effects are difficult to achieve through oral delivery alone

IV NAD+ administration bypasses all of these limitations. The NAD+ is delivered directly into the bloodstream at concentrations that produce immediate, measurable increases in cellular NAD+ levels — producing effects that oral supplementation simply cannot replicate.

What Are the Benefits of NAD+ IV Therapy?

The clinical and research evidence for NAD+ IV therapy spans multiple domains:

Energy and Mitochondrial Function

Patients consistently report significant increases in energy, stamina, and physical vitality following NAD+ infusions. This reflects the direct restoration of mitochondrial function — the cells’ power plants are simply running better.

Cognitive Performance and Brain Health

NAD+ is particularly important for brain health. It supports neuronal function, protects against neurodegeneration, and promotes the production of neurotrophic factors that support brain plasticity. Patients undergoing NAD+ therapy frequently report improvements in mental clarity, focus, memory, and processing speed — often described as a “lifting of mental fog” that had become accepted as normal.

Anti-Aging at the Cellular Level

By activating sirtuin enzymes and supporting robust DNA repair, NAD+ therapy addresses aging at the biological root — not just its surface manifestations. Research in animal models has shown that NAD+ restoration can reverse markers of cellular aging, and human studies are increasingly confirming similar effects in domains including muscle function, metabolic health, and cardiovascular function.

Mood and Mental Health

NAD+ plays a role in the synthesis of serotonin — the key neurotransmitter involved in mood regulation. Low NAD+ levels have been associated with anxiety, depression, and mood instability. Many patients undergoing NAD+ therapy report meaningful improvements in mood, emotional resilience, and general sense of wellbeing.

Addiction Recovery Support

NAD+ IV therapy has been used in addiction medicine for several decades, particularly in the United States, where high-dose protocols have shown striking results in reducing withdrawal symptoms and cravings for alcohol, opioids, and stimulants. The mechanism relates to NAD+’s role in the brain reward system and its ability to rapidly restore neurological function following the damage caused by substance abuse.

Metabolic Health

NAD+ is closely involved in glucose metabolism and insulin sensitivity. Restoring NAD+ levels supports healthy metabolic function, which is relevant not only for people with metabolic syndrome or pre-diabetes, but for anyone seeking to optimise body composition and long-term health.

What to Expect from NAD+ IV Therapy at Neo Clinics

NAD+ infusions are longer than standard IV therapy sessions — typically 2–4 hours — because NAD+ must be administered slowly to avoid transient side effects such as nausea, flushing, or chest tightness. These sensations are harmless and resolve immediately if the infusion rate is reduced, but our team monitors all patients closely throughout to ensure maximum comfort.

Most patients are surprised by how comfortable and even enjoyable the sessions are. Many bring a book, laptop, or headphones and use the time productively.

A standard NAD+ programme at Neo Clinics consists of an initial intensive course — typically 4–10 sessions over one to two weeks — followed by monthly maintenance infusions to sustain elevated NAD+ levels over the long term.

Who Is NAD+ IV Therapy For?

NAD+ therapy is suitable for a wide range of patients, including:

• Those experiencing age-related fatigue, cognitive decline, or physical deterioration
• Patients with chronic fatigue syndrome or post-viral fatigue
• Individuals seeking longevity and anti-aging optimisation
• Athletes and high performers seeking cognitive and physical enhancement
• Patients with mood disorders or neurological symptoms
• Those in recovery from addiction
• Anyone who has noticed a significant decline in energy, mental sharpness, or overall vitality

NAD+ Therapy at Neo Clinics, Girona

At Neo Clinics, NAD+ IV therapy is always delivered within a comprehensive regenerative medicine framework. Before beginning treatment, we assess your health profile, review your goals, and — where appropriate — use blood testing and biomarker analysis to establish your baseline and track your progress.

Our clinic is led by Dr. Ingmar Blom, with deep expertise in longevity medicine and advanced IV therapy protocols. We serve patients from across Girona, the Costa Brava, Catalonia, and throughout Spain and Europe.

Book your NAD+ IV therapy consultation today. No referral required.

📍 Av. de la Platja, 94, Castell-Platja d’Aro, Girona

📞 +34 662 490 672

🌐 neo-clinics.es/en/infusion-therapy/